Endocrine Abstracts

Context: Hypothalamic-pituitary-adrenal axis (HPA) may be disrupted by drugs, including opioids. Opioids are widely used for treatment of acute and chronic pain, but they also carry a wide range of adverse effects. Opioid receptors are present in the pituitary gland and hypothalamus and chronic use of opioids may lead to adrenal insufficiency because of central suppression of the hypothalamic-pituitary-adrenal axis (HPA).Case Presentation: We report a 26...

Autoimmune polyglandular syndromes (APS) are a group of immune-endocrine syndromes that cause autoimmune destruction of multiple endocrine organs. The most common in this group is APS type 2, which frequently presents with primary adrenal insufficiency with autoimmune thyroid disease and/or type 1 diabetes mellitus. We present a case of 46 year old male, with no significant medical history who presented in our clinic with: weakness, fatigue and weight loss for the preceding la...

Background: Primary aldosteronism (PA) is a group of disorders characterized with inappropriately high adrenal aldosterone production, suppressed renin and hypertension. Prevalence of PA is approximately 5-10% in people with hypertension and up to 20-50% in those with resistant hypertension. PA is associated with increased cardiovascular and cerebrovascular morbidity and mortality rates compared with patients with essential hypertension when matched with age, sex and blood pre...

Hyponatremia is the most common disorder of electrolytes encountered in clinical practice, occurring in 15-30% of acutely or chronically hospitalized patients. Although many cases are mild and relatively asymptomatic, hyponatremia is nonetheless important clinically because: acute severe hyponatremia can cause substantial morbidity and mortality; overly rapid correction of chronic hyponatremia can cause severe neurological deficits and death. We present Clinical cases of endoc...

Title: Pulmonary Embolism in Surgically Treated Cushing’s Disease: A Case ReportAuthors: Qetevan Gvazava1, Nino Zavrashvili1, Natia Margvelashvili2, Natia Shonia2, Ketevan Chanturishvili2 Endocrinology Department, Tbilisi Institute of MedicineBackground: Cushing’s disease is the most common cause of Cushing’s syndrome but can be very difficult to diagnose and to treat. as we know it has numerous health effects on pat...